Chelerythrine chloride

Supplier: 0000027161

Synonyms: 1,2-Dimethoxy-12-methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-ium chloride

AG-CR1-0071-M001 AG-CR1-0071-M005 AG-CR1-0071-M025

102988-534EA 34.62 USD

102988-534 102988-536 102988-538

Chelerythrine chloride

Chelerythrine chloride

Cell permeable potent inhibitor of protein kinase C. Does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase or calcium/calmodulin-dependent protein kinase. Antiplatelet, anti-inflammatory, antibacterial and antitumor compound. Apoptosis inducer in cancer cells in vitro and in vivo. Activates MAPK and JUNK signaling pathways. Affects translocation of PKC from cytosol to plasma membrane. Neurite outgrowth stimulator. Inhibits binding of BclXL to Bak (IC50 = 1.5 µM) or Bad proteins and stimulates apoptosis in several cancer cell lines. Blocks human P2X7 receptor. Induces cell cycle arrest in G1 phase. Specific cyclooxygenase-2 inhibitor.

Formula: C₂₁H₁₈ClNO₄

MDL Number: MFCD00060717
CAS Number: 3895-92-9

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