Anti-CASP8 Monoclonal Antibody [clone: 1G12]

Supplier: Adipogen

AG-20T-0137-C100

102978-630EA 401.54 USD

102978-630

Anti-CASP8 Monoclonal Antibody [clone: 1G12]

Antibodies

Procaspase-8 belongs to the family of caspases. Binding of FasL to Fas leads to formation of a receptor complex at the cellular membrane, which was named DISC. The DISC consists of oligomerized receptors, the DD-containing adaptor molecule FADD, procaspase-8, procaspase-10 and c-FLIP. The DISC structure provides a platform for the oligomerization of procaspase-8 that allows two procaspase-8 homodimers to be in the close proximity leading to the initial activation of procaspase-8. At the first cleavage step, the N-terminal p43/p41 and the C-terminal p30 cleavage products are generated. Importantly, these cleavage products already possess catalytic activity. At the second cleavage step, p43/p41 and p30 are processed to p10 and p20, respectively, which leads to the generation of the active caspase-8 heterotetramer (p20/p10)2.

Type: Primary
Antigen: CASP8
Clonality: Monoclonal
Clone: 1G12
Conjugation: Unconjugated
Epitope:
Host:
Isotype: Rat IgG1kappa
Reactivity: Mouse

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