Anti-NLRC3 Monoclonal Antibody [clone: Eowyn-1]

Supplier: Adipogen

AG-20B-0067-C100

102971-624EA 553.85 USD

102971-624

Anti-NLRC3 Monoclonal Antibody [clone: Eowyn-1]

Antibodies

The novel nucleotide oligomerization domain (NOD)-like receptor (NLR) with a caspase activation and recruitment domain (CARD) 3 (NLRC3) protein belongs to the NLR family of cytosolic pathogen recognition receptors. NLRC3 has the characteristic NOD and leucine-rich repeat configuration with a less well defined CARD. NLRC3 is expressed in T lymphocytes and may be involved in suppression of T cell activation. NLRC3 is a cytoplasmic protein that negatively regulates pro-IL-1beta maturation and inhibits toll-like receptor (TLR)-dependent activation of the transcription factor NF-kappaB. NLRC3 interacts with the TLR signaling adaptor TRAF6 to attenuate Lys63 (K63)-linked ubiquitination of TRAF6 and activation of NF-kappaB. NLRC3 also reduces STING-dependent innate immune activation in response to cytosolic DNA, cyclic di-GMP (c-di-GMP) and DNA viruses. NLRC3 associated with both STING and TBK1, impedes STING-TBK1 interaction and downstream type I interferon production.

Type: Primary
Antigen: NLRC3
Clonality: Monoclonal
Clone: Eowyn-1
Conjugation: Unconjugated
Epitope:
Host:
Isotype: Mouse IgG1
Reactivity: Mouse

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