Kdo2-Lipid A 0,5 mg/mL ready-to-use, sterile
Supplier: 0000027161
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Warning
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Synonyms:
(3-Deoxy-D-manno-octulosonic acid)2-Lipid A
Defined substructure of the Re mutant of lipopolysaccharide (LPS). Endotoxin activity equal to Re LPS. Strong activator (<10ng/ml) of macrophages via toll-like receptor 4 (TLR4). Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice by IL-6 ELISA. Facilitates the structural analysis of its complexes with signaling receptors, such as TLR4/MD2 and CD14. Kdo2-Lipid A was used in a recent animal atherosclerosis model. Induces sphingolipid biosynthesis, which is essential for induction of autophagy.
Source/Hos:t Isolated and purified from E. coli K12 heptose-deficient strain WBB06 (Re mutant).
Purity: Absence of detectable protein or DNA contaminants with agonistic TLR activity.
Appearance: Clear, colorless solution.
Formulation: Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.
Concentration: 0.5 mg/ml. Vial contains 2 ml.
Short Term Storage +4°C
Long Term Storage +4°C
Keep sterile. Do not ingest. Wear gloves and mask. Avoid contact through all modes of exposure. Avoid inhalation and prevent from entering the bloodstream. Use must be restricted to qualified personnel.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C
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Formula:
C₁₁₀H₁₉₈N₂Na₄O₃₉P₂ Storage Temperature: Refrigerator |
CAS Number:
123621-04-5 |
Specification Test Results
| Source/Host | Isolated and purified from E. coli K12 heptose-deficient strain WBB06 (Re mutant). |
| Purity | Absence of detectable protein or DNA contaminants with agonistic TLR activity. |
| Appearance/Color | Clear, colorless solution. |
| Formulation | Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water. |
| Concentration | 0.5 mg/ml. Vial contains 2 ml. |
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