Anti-NAIP1/2/5 Mouse Monoclonal Antibody [clone: Naipa-1]

Supplier: Adipogen

AG-20B-0045-C100

102514-362EA 540 USD

102514-362

Anti-NAIP1/2/5 Mouse Monoclonal Antibody [clone: Naipa-1]

Antibodies

The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. The NLR member IPAF/NLRC4 senses bacterial flagellin and a conserved type III secretion system (TTSS) rod component. A member of the NLR family, NAIP5 directly and specifically interacts with flagellin, triggers a physical NAIP5-NLRC4 association leading to NLRC4 activation. The related NAIP2 functions analogously to NAIP5, serving as a specific inflammasome receptor for TTSS rod proteins such as Salmonella PrgJ and Burkholderia BsaK.

Stable for at least 1 year after receipt when stored at -20°C.

Purified from concentrated hybridoma tissue culture supernatant.

Purity: >95% (SDS-PAGE)

Type:
Antigen: NAIP1/2/5
Clonality: Monoclonal
Clone: Naipa-1
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Mouse

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