Anti-Cardif Mouse Monoclonal Antibody [clone: Adri-1]

Supplier: Adipogen
AG-20B-0004-C100
102514-260EA 498.46 USD
102514-260
Anti-Cardif Mouse Monoclonal Antibody [clone: Adri-1]
Antibodies
RIG-I (retinoic acid-inducible gene I; Ddx58) and MDA5 (melanoma differentiation-associated gene 5, also known as Ifih1 or Helicard) are proteins that sense viral replication intermediates, such as double-stranded RNA and triggers the host antiviral programs. These molecules signal the downstream activation of NF-kappaB and IFN regulatory factor (IRF) -3, which coordinately regulate the expression of type-I interferons. Cardif (also called VISA/IPS-1/MAVS) is a new CARD (caspase activation and recruitment domain)-containing adaptor protein that interacts with the CARD domain of RIG-I and MDA5, leading to the activation of NF-kappaB and IRF3. Cardif is located to the mitochondrial outer membrane. Removal of the mitochondrial-targeting domain of cardif abolishes its ability to induce IFNs. Cardif is cleaved and inactivated by NS3-4A, a serine protease from hepatitis C virus known to block interferon-beta production.

  • Stable for at least 1 year after receipt when stored at -20°C.

Purified from concentrated hybridoma tissue culture supernatant.

Purity: >95% (SDS-PAGE)

Type:
Antigen: Cardif
Clonality: Monoclonal
Clone: Adri-1
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG2b
Reactivity: Human
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