Anti-ZBTB7B Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-ZBTB7B Rabbit Polyclonal Antibody

Anti-ZBTB7B Rabbit Polyclonal Antibody

Anti-ZBTB7B Rabbit Polyclonal Antibody

Anti-ZBTB7B Rabbit Polyclonal Antibody

Anti-ZBTB7B Rabbit Polyclonal Antibody

Anti-ZBTB7B Rabbit Polyclonal Antibody

11341-1-AP-150UL

10097-250EA 462.47 USD

10097-250

Anti-ZBTB7B Rabbit Polyclonal Antibody

Antibodies

ZBTB7B belongs to a large family of transcription factors, generally acting as repressors, characterized by a carboxy-terminal DNA binding domain made of multiple zinc fingers (four in Thpok) and an amino-terminal BTB-POZ domain that mediates homo- (and possibly hetero-) dimerization . Zbtb7b is up-regulated by MHC-II-restricted thymocytes during their CD4 differentiation and is a major determinant of CD4 lineage choice. Two properties of ZBTB7B deserve attention. First, although Thpok is expressed in a wide variety of cells, its expression in the thymus is highly lineage-specific : CD4 SP thymocytes (and all CD4 T cells) express Thpok, whereas DP and CD8 SP thymocytes do notSecond, both loss- and gain-of-function experiments indicate that Thpok affects lineage choice but not positive selection .

Western Blot: Human skin Tissue, 1:200-1:2000; IF: Hela, 1:10-1:100

Type: Primary
Antigen: ZBTB7B
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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