Anti-TDG Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-TDG Rabbit Polyclonal Antibody

Anti-TDG Rabbit Polyclonal Antibody

Anti-TDG Rabbit Polyclonal Antibody

Anti-TDG Rabbit Polyclonal Antibody

Anti-TDG Rabbit Polyclonal Antibody

Anti-TDG Rabbit Polyclonal Antibody

13370-1-AP-150UL

10095-754EA 462.47 USD

10095-754

Anti-TDG Rabbit Polyclonal Antibody

Antibodies

TDG belongs to the TDG/mug DNA glycosylase family. TDG corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine. RNF4 interacts with and requires the base excision repair enzymes TDG and APE1 for active demethylation . TDG is modified by SUMO-1 and SUMO-2/3.The molecular weight of non-modified TDG is 60 kDa and modified TDG is 86 kDa.

Western Blot: Human Brain Tissue, 1:500-1:5000; IP:U-937 Cells, 1:200-1:1000

Type: Primary
Antigen: TDG
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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