Anti-RRM1 Mouse Monoclonal Antibody [clone: 5H6F3]

Supplier: Proteintech
60073-2-IG-150UL
10093-998EA 462.47 USD
10093-998
Anti-RRM1 Mouse Monoclonal Antibody [clone: 5H6F3]
Antibodies
Ribonucleoside-diphosphate reductase functions as a heterodimer of a large and a small subunits in deoxyribonucleotide synthesis. RRM1 constitutes to the large subunit (R1) of ribonucleotide reductase, and it can either form heterodimer with small subunit RRM or RRM2B. RRM1 provides the precursors necessary for DNA synthesis. RRM1 can not be detected in quiescent cells, while its mRNA and protein are present throughout the cell cycle in cycling cells. Researches showed that RRM1 is involved in carcinogenesis, tumor progression, and the resistance of non-small-cell lung cancer (NSCLC) to treatment. Low level expression of RRM1 in NSCLC is associated with poor survival.

Western Blot:K-562 Cells, 1:500-1:5000; IHC: Human lung cancer Tissue, 1:20-1:200; IF: HepG2 Cells, 1:20-1:200

Type: Primary
Antigen: RRM1
Clonality: Monoclonal
Clone: 5H6F3
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2b
Reactivity: Human
Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR