Anti-PMS2 Mouse Monoclonal Antibody [clone: 1G4E6]

Supplier: Proteintech
66075-1-IG-150UL
10092-302EA 462.47 USD
10092-302
Anti-PMS2 Mouse Monoclonal Antibody [clone: 1G4E6]
Antibodies
PMS2, also named as PMSL2, belongs to the DNA mismatch repair mutL/hexB family. It is a component of the post-replicative DNA mismatch repair system (MMR). It heterodimerizes with MLH1 to form MutL alpha. MulL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. It also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Defects in PMS2 are the cause of hereditary non-polyposis colorectal cancer type 4 (HNPCC4). Defects in PMS2 are a cause of mismatch repair cancer syndrome (MMRCS).

Western Blot:A431 Cells, 1:500-1:5000

Type: Primary
Antigen: PMS2
Clonality: Monoclonal
Clone: 1G4E6
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Human
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