Anti-OPTN Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-OPTN Rabbit Polyclonal Antibody

Anti-OPTN Rabbit Polyclonal Antibody

Anti-OPTN Rabbit Polyclonal Antibody

Anti-OPTN Rabbit Polyclonal Antibody

Anti-OPTN Rabbit Polyclonal Antibody

Anti-OPTN Rabbit Polyclonal Antibody

Anti-OPTN Rabbit Polyclonal Antibody

Anti-OPTN Rabbit Polyclonal Antibody

Anti-OPTN Rabbit Polyclonal Antibody

Anti-OPTN Rabbit Polyclonal Antibody

Anti-OPTN Rabbit Polyclonal Antibody

Anti-OPTN Rabbit Polyclonal Antibody

10837-1-AP-150UL

10091-594EA 462.47 USD

10091-594

Anti-OPTN Rabbit Polyclonal Antibody

Antibodies

OPTN, also named as FIP2, GLC1E, HIP7, HYPL and NRP, plays a neuroprotective role in the eye and optic nerve. It is probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. OPTN may act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). OPTN may constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death. Defects in OPTN are the cause of primary open angle glaucoma type 1E (GLC1E). Defects in OPTN are a cause of susceptibility to normal pressure glaucoma (NPG). OPTN mutated in adult-onset primary open angle glaucoma. It supports the protective role of OPTN in the trabecular meshwork.

Western Blot: HeLa Cells, 1:500-1:5000; IHC: Human pancreas cancer Tissue, 1:20-1:200; IF: MCF-7 Cells, 1:10-1:100; IP: Mouse Brain Tissue, 1:200-1:2000

Type: Primary
Antigen: OPTN
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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