Anti-FOXO1 Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-FOXO1 Rabbit Polyclonal Antibody

Anti-FOXO1 Rabbit Polyclonal Antibody

Anti-FOXO1 Rabbit Polyclonal Antibody

Anti-FOXO1 Rabbit Polyclonal Antibody

18592-1-AP-150UL

10087-122EA 462.47 USD

10087-122

Anti-FOXO1 Rabbit Polyclonal Antibody

Antibodies

FOXO1, also named as FOXO1A, FKHR and FKH1, is a member of the FOXO subfamily of Forkhead transcription factors. FOXO1 is a transcription factor which acts as a regulator of cell responses to oxidative stress. FOXO1 interacts with LRPPRC and SIRT1. In the presence of KIRT1, FOXO1 mediates down-regulation of cyclin D1 and up-regulation of CDKN1B levels which are required for cell transition from proliferative growth to quiescence. FOXO1 contains three predicted protein kinase B phosphorylation sites (Thr-24, Ser-256, and Ser-319) that are conserved in other FOXO proteins. The t(2;13) and the variant t(1;13) translocations generate PAX3/FKHR and PAX7/FKHR fusion proteins respectively. The resulting protein is a transcriptional activator. Defects in FOXO1 are a cause of rhabdomyosarcoma type 2 (RMS2).

Western Blot: HeLa Cells, 1:200-1:2000

Type: Primary
Antigen: FOXO1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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