Anti-CUL4A Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-CUL4A Rabbit Polyclonal Antibody

Anti-CUL4A Rabbit Polyclonal Antibody

10693-1-AP-150UL

10085-350EA 462.47 USD

10085-350

Anti-CUL4A Rabbit Polyclonal Antibody

Antibodies

Cullin proteins assemble a large number of RING E3 ubiquitin ligases, participating in the proteolysis through the ubiquitin-proteasome pathway. Two cullin 4 (CUL4) proteins, CUL4A (87 kDa) and CUL4B(104 kDa), have been identified. The two CUL4 sequences are 83% identical. They target certain proteins for degradation by binding protein DDB1 to form a CUL4-DDB1 ubiquitin ligase complex with DDB. They form two individual E3 ligases, DDB1-CUL4ADDB2 and DDB1-CUL4BDDB2 in this process. CUL4A appeared in both the nucleus and the cytosol, suggesting a more complex mechanism for entering the nucleus. CUL4B is localized in the nucleus and facilitates the transfer of DDB1 into the nucleus independently of DDB2. This antibody can bind both CUL4A and CUL4B.

IHC: Human breast cancer Tissue, 1:20-1:200

Type: Primary
Antigen: CUL4A
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity:

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