Anti-CHMP2B Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-CHMP2B Rabbit Polyclonal Antibody

Anti-CHMP2B Rabbit Polyclonal Antibody

Anti-CHMP2B Rabbit Polyclonal Antibody

Anti-CHMP2B Rabbit Polyclonal Antibody

Anti-CHMP2B Rabbit Polyclonal Antibody

Anti-CHMP2B Rabbit Polyclonal Antibody

Anti-CHMP2B Rabbit Polyclonal Antibody

Anti-CHMP2B Rabbit Polyclonal Antibody

12527-1-AP-150UL

10084-718EA 462.47 USD

10084-718

Anti-CHMP2B Rabbit Polyclonal Antibody

Antibodies

CHMP2B, chromatin-modifying protein 2b, also named as CHMP2.5, VPS2B and VPS2 2, belongs to the chromatin-modifying protein / charged multivesicular body protein (CHMP) family. It is a component of endosomal sorting complex required for transport III (ESCRT-III), which involves in endosomal and autophagic trafficking of proteins to lysosomes for degradation. Mutations of CHMP2B lead to C-terminal truncation or been replaced with mis-splicing C-termini and cause frontotemporal lobar degeneration (FTLD). In CHMP2B mutation patients, p62- and ubiquitin-positive, but TDP-43 and FUS negative neural inclusions are formed, maybe caused by impaired lysosomal degradation through the autophagy and endosome-lysosome pathways.

Western Blot:SH-SY5Y Cells, 1:200-1:2000; IF: HepG2 Cells, 1:10-1:100; IHC: Human Liver Tissue, 1:20-1:200

Type: Primary
Antigen: CHMP2B
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity:

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