Anti-ATPIF1 Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-ATPIF1 Rabbit Polyclonal Antibody

Anti-ATPIF1 Rabbit Polyclonal Antibody

Anti-ATPIF1 Rabbit Polyclonal Antibody

Anti-ATPIF1 Rabbit Polyclonal Antibody

12067-1-AP-150UL

10083-394EA 462.47 USD

10083-394

Anti-ATPIF1 Rabbit Polyclonal Antibody

Antibodies

The H(+)-ATP synthase is a reversible engine of mitochondria that synthesizes or hydrolyzes ATP upon changes in cell physiology. ATP synthase dysfunction is involved in the onset and progression of diverse human pathologies. ATPIF1 gene encodes mitochondrial ATPase Inhibitory Factor 1 (IF1), also named ATPI, ATPIP or IP. Endogenous IF1 limits ATP depletion when the mitochondrial membrane potential falls below a threshold and the ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Mitochondrial content of IF1 controls the activity of oxidative phosphorylation mediating the shift of cancer cells to an enhanced aerobic glycolysis, thus supporting an oncogenic role of IF1 in cancer.

Western Blot: HeLa Cells, 1:500-1:5000

Type: Primary
Antigen: ATPIF1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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