Anti-ATF4 Rabbit Polyclonal Antibody

Supplier: Proteintech
10835-1-AP-150UL
10083-232EA 462.47 USD
10083-232
Anti-ATF4 Rabbit Polyclonal Antibody
Antibodies
ATF4 is a transcription factor, that accumulates predominantly in osteoblasts, where it regulates terminal osteoblast differentiation and bone formation. As a basic leucine-zipper (bZip) transcription factor, ATF4 can regulate amino acid metabolism, cellular redox state, and anti-stress responses. It also regulates age-related and diet-induced obesity and glucose homeostasis in mammals, and has conserved metabolic functions in flies. Due to its location at chromosome 22q13, a region linked to schizophrenia, ATF4 is considered as a positional candidate gene for schizophrenia. Otherwise, since ATF4 is induced by tumour microenvironmental factors, and regulates processes relevant to cancer progression, it might serve as a potential therapeutic target in cancer. Endogenous ATF4 protein has a molecular mass of 50kd. . This antibody is a rabbit polyclonal antibody raised against full length human ATF4 antigen. The antibody recognizes the 38kd ATF4 protein and its phosphorylated forms (50kd).

  • Western Blot:A431 Cells, 1:200-1:2000; IHC: Human breast cancer Tissue, 1:20-1:200; IP: HEK-293 Cells, 1:200-1:1000; FC: MCF-7 Cells, N/A

Type: Primary
Antigen: ATF4
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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