Anti-PARP1 Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-PARP1 Rabbit Polyclonal Antibody

Anti-PARP1 Rabbit Polyclonal Antibody

Anti-PARP1 Rabbit Polyclonal Antibody

Anti-PARP1 Rabbit Polyclonal Antibody

13371-1-AP-150UL

10081-700EA 462.47 USD

10081-700

Anti-PARP1 Rabbit Polyclonal Antibody

Antibodies

PARP1 (poly(ADP-ribose) polymerase 1) is a nuclear enzyme catalyzing the poly(ADP-ribosyl)ation of many key proteins in vivo. The normal function of PARP1 is the routine repair of DNA damage. Activated by DNA strand breaks, the PARP1 is cleaved into an 85 to 89-kDa COOH-terminal fragment and a 24-kDa NH2-terminal peptide by caspases during the apoptotic process. The appearance of PARP fragments is commonly considered as an important biomarker of apoptosis. In addition to caspases, other proteases like calpains, cathepsins, granzymes and matrix metalloproteinases (MMPs) have also been reported to cleave PARP1 and gave rise to fragments ranging from 42-89-kD. This antibody was generated against the C-terminal region of human PARP1 and it recognizes the full-length as well as the cleavage of the PARP1.

Western Blot:Fas antibody treated HeLa Cells, 1:500-1:5000; IP:K-562 Cells, 1:200-1:2000

Type: Primary
Antigen: PARP1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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